Research Interests – Laboratory of Clinical Virology
March 30, 2026 2026-05-08 10:57Research Interests – Laboratory of Clinical Virology
Published in: Cellular Physiology and Biochemistry.
The role of RhoA, RhoB and RhoC GTPases in cell morphology, proliferation and migration in human cytomegalovirus (HCMV) infected glioblastoma cells.
Melpomeni Tseliou1, Ahmed Al-Qahtani2, Saud Alarifi3, Saad Η. Alkahtani3, Christos Stournaras4*, George Sourvinos1*
* These authors share equal senior authorship:
1Laboratory of Virology, Medical School, University of Crete, Heraklion, Crete, Greece.
2Department of Biological & Medical Research, Research Center, King Faisal Hospital & Research Center, Riyadh, Saudi Arabia.
3Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
4Department of Biochemistry, Medical School, University of Crete, Heraklion, Crete, Greece.
The role of RhoA, RhoB and RhoC GTPases in cell morphology, proliferation and migration in human cytomegalovirus (HCMV) infected glioblastoma cells.
Melpomeni Tseliou1, Ahmed Al-Qahtani2, Saud Alarifi3, Saad Η. Alkahtani3, Christos Stournaras4*, George Sourvinos1*
* These authors share equal senior authorship:
1Laboratory of Virology, Medical School, University of Crete, Heraklion, Crete, Greece.
2Department of Biological & Medical Research, Research Center, King Faisal Hospital & Research Center, Riyadh, Saudi Arabia.
3Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
4Department of Biochemistry, Medical School, University of Crete, Heraklion, Crete, Greece.
Video legend:
U373MG and U373MG-IE1 cell motility after depletion of RhoA, RhoB or RhoC in uninfected or HCMV infected cells.
Both the parental U373MG and the derivatives U373MG-IE1 cells were transduced with the indicated shRNA TRIPZ lentivirus vectors and subsequently infected with HCMV (MOI=3 pfu/cell ) or not.
After 48 hours of infection (mock or HCMV), images were acquired by time-lapse microscopy every 15 min for 5 h.
The replay speed is 200 min/s.
