Illumina NextSeq 2000 Sequencing System
September 1, 2026 2026-09-01 10:04Illumina NextSeq 2000 Sequencing System
Illumina NextSeq 2000 Sequencing System
Brief Description
The Illumina NextSeq 2000 is an advanced next-generation sequencing (NGS) platform designed for rapid, flexible, and high-quality genomic analysis. Using Illumina’s Sequencing by Synthesis (SBS) technology, the system can generate hundreds of millions to over one billion sequencing reads per run with exceptional accuracy. It supports a broad range of applications, including whole-genome sequencing (WGS), RNA sequencing (RNA-Seq), metagenomics, targeted sequencing, and single-cell genomics. Multiple flow cell configurations allow data output to be tailored to the requirements of individual projects, making the NextSeq 2000 an ideal solution for medium- to high-throughput sequencing.Specifications
Platform Overview
The NextSeq 2000 is a high-throughput sequencing platform designed for large-scale genomic and transcriptomic studies while maintaining the compact footprint of a benchtop instrument. It is based on the NextSeq 1000 architecture but supports higher-capacity P3 and P4 flow cells, enabling substantially increased data output.
Using XLEAP-SBS chemistry, the system can generate up to 540 Gb of sequencing data per run, depending on the selected flow cell and read configuration.
Sequencing Performance
- Data output: Up to 540 Gb per run
- Read lengths: Up to 2 × 300 bp
- Quality scores: Typically >90% of bases ≥ Q30 for read lengths up to 150 bp
Integrated Computing
- 2U microserver
- 288 GB RAM
- 3.8 TB SSD storage
- Linux CentOS operating system
- Integrated DRAGEN FPGA-accelerated secondary analysis for rapid onboard processing
Optical System
- Three laser sources:
- 449 nm
- 523 nm
- 820 nm
- Class 1 laser device
Physical Specifications
- Dimensions: 55 × 65 × 60 cm
- Weight: Approximately 141 kg
Supported Applications
- Whole-genome sequencing (WGS)
- Whole-exome sequencing (WES)
- Large-scale RNA-Seq studies
- Single-cell RNA sequencing
- Comprehensive tumor genomic profiling
- Large-scale microbiome studies
The combination of high throughput and integrated bioinformatics makes the NextSeq 2000 particularly well suited for large genomic studies, clinical genomics, and population-scale sequencing projects.
Additional information
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