Στο εργαστήριό μας μελετούμε πώς τα φλοιώδη κυκλώματα αλληλεπιδρούν για να δημιουργήσουν αναπαραστάσεις αντικειμένων που παραμένουν σταθερές παρά τις μεταμορφώσεις και μπορούν να καθοδηγήσουν τη συμπεριφορά. Το φυσικό περιβάλλον περιλαμβάνει έναν τεράστιο αριθμό αντικειμένων με αλληλεπικαλυπτόμενα αισθητηριακά ερεθίσματα, και ο εγκέφαλός μας διαθέτει την εντυπωσιακή ικανότητα να συνδυάζει πληροφορίες από διαφορετικές αισθητηριακές οδούς ώστε να αναγνωρίζει εύκολα την ταυτότητά τους. Ωστόσο, παρά την εκτεταμένη έρευνα των τελευταίων δεκαετιών, απέχουμε ακόμη πολύ από μια πλήρη κατανόηση του πώς ο εγκέφαλος καταφέρνει να δημιουργεί αυτές τις «ξεκαθαρισμένες» αναπαραστάσεις.
Η αποκωδικοποίηση του τρόπου με τον οποίο ο φλοιός επιτυγχάνει αυτή την εξαιρετική ικανότητα σε αλγοριθμικό επίπεδο θα αποτελούσε σημαντική πρόοδο στην κατανόηση των μηχανισμών υπολογισμού του εγκεφάλου συνολικά. Για να προσεγγίσουμε αυτό το ερώτημα, συνδυάζουμε προηγμένες απεικονιστικές τεχνικές για την καταγραφή νευρικής δραστηριότητας με μεθόδους εκπαίδευσης συμπεριφοράς υψηλής απόδοσης και υπολογιστική μοντελοποίηση. Στόχος μας είναι να αποκαλύψουμε τον «αλγόριθμο» που χρησιμοποιεί ο οπτικός φλοιός του ποντικού για να εξάγει κρίσιμα χαρακτηριστικά από πολύπλοκα περιβάλλοντα και να καθοδηγεί φυσικές συμπεριφορές.

Google Scholar: https://scholar.google.com/citations?user=peGMCr8AAAAJ&hl

A. Άρθρα με κριτές
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B. Συνεδριακά άρθρα με κριτές
• Ustyuzhaninov, I., Cadena, S.A., Froudarakis, E., Fahey, P.G., Walker, E.Y., Cobos, E., Reimer, J., Sinz, F.H., Tolias, A.S., Bethge, M., and Ecker, A.S. (2020). Rotation-invariant clustering of neuronal responses in primary visual cortex. Eighth International Conference on Learning Representations 2020
• Cadena, S.A., Sinz, F.H., Muhammad, T., Froudarakis, E., Cobos, E., Walker, E.Y., Reimer, J., Bethge, M., Tolias, A., and Ecker, A.S. (2019). How well do deep neural networks trained on object recognition characterize the mouse visual system? In NeurIPS Neuro AI Workshop.
• Sinz, H. F., Ecker, A., Fahey, G. P., Walker, Y. E., Cobos, E., Froudarakis, E., Yatsenko, D., Pitkow, X., Reimer, J., Tolias, A.S. (2018). Stimulus domain transfer in recurrent models for large scale cortical population prediction on video. Neural Information Processing Systems

Γ. Προδημοσιευμένα άρθρα (χωρίς κριτές)
• Franke, K., Karantzas, N., Willeke, K., Diamantaki, M., Ramakrishnan, K., Elumalai, P., Restivo, K., Fahey, P., Nealley, C., Shinn, T., Garcia, G., Patel, S., Ecker, A., Walker, E.Y., Froudarakis, E., Sanborn, S., Sinz, F.H., Tolias, A. (2025). Dual-feature selectivity enables bidirectional coding in visual cortical neurons. bioRxiv 2025.07.16.665209.
• Papageorgiou, T.D., Webb, J., Allam, A., Rohren, E.M., Sturgis, E.M., Hutcheson, K., Heilbronner, S.R., Froudarakis, E. (2025). Individualized fMRI neuromodulation enhances swallow and tongue motor and sensory control: an intervention targeted for radiation-induced cranial neuropathy following head and neck cancer. bioRxiv 2025.04.30.651533.
• Macrina, T., Lee, K., Lu, R., Turner, N.L., Wu, J., Popovych, S., Silversmith, W., Kemnitz, N., Bae, J.A., Castro, M.A., Dorkenwald, S., Halageri, A., Jia, Z., Jordan, C., Li, K., Mitchell, E., Mondal, S.S., Mu, S., Nehoran, B., Wong, W., Yu, S., Bodor, A.L., Brittain, D., Buchanan, J., Bumbarger, D.J., Cobos, E., Collman, F., Elabbady, L., Fahey, P.G., Froudarakis, E., Kapner, D., Kinn, S., Mahalingam, G., Papadopoulos, S., Patel, S., Schneider-Mizell, C.M., Sinz, F.H., Takeno, M., Torres, R., Yin, W., Pitkow, X., Reimer, J., Tolias, A.S., Reid, R.C., Costa, N.M. da, and Seung, H.S. (2021). Petascale neural circuit reconstruction: automated methods. bioRxiv 2021.08.04.455162.
• Froudarakis, E., Cohen, U., Diamantaki, M., Walker, E.Y., Reimer, J., Berens, P., Sompolinsky, H., and Tolias, A.S. (2020). Object manifold geometry across the mouse cortical visual hierarchy. bioRxiv, 2020.08.20.258798.
• Zhou, P., Reimer, J., Zhou, D., Pasarkar, A., Kinsella, I., Froudarakis, E., Yatsenko, D.V., Fahey, P.G., Bodor, A., Buchanan, J., et al. (2020). EASE: EM-Assiste Source Extraction from calcium imaging data. bioRxiv, 2020.03.25.007468.
• Fahey, P.G., Muhammad, T., Smith, C., Froudarakis, E., Cobos, E., Fu, J., Walker, E.Y., Yatsenko, D., Sinz, F.H., Reimer, J., et al. (2019). A global map of orientation tuning in mouse visual cortex. bioRxiv, 745323.
• Ecker A.S., Sinz F.H., Froudarakis E., Fahey P.G., Cadena S.A., Walker E.Y., Cobos E., Reimer J., Tolias A.S., Bethge M. A rotation-equivariant convolutional neural network model of primary visual cortex ArXiv:1809.10504 (2018)

Μέλος της Ομοσπονδίας Ευρωπαϊκών Εταιρειών Νευροεπιστημών (FENS)
Μέλος της Ελληνικής Εταιρείας για τις Νευροεπιστήμες
Μέλος του Διεθνούς Οργανισμού Έρευνας Εγκεφάλου (IBRO)