George Liapakis is Professor of Pharmacology in the School of Medicine, University of Crete, and his research interests focus on studying the structure and function of the G-protein coupled receptors (GPCRs), which are targets for approximately 35% of commercially available drugs. He has been working on families A and B GPCRs since he started his PhD. After the completion of his PhD he joined the Department of Pharmacology of the Medical School at the University of Pennsylvania (UPENN) in Philadelphia, USA, as a postdoctoral fellow, where using a variety of experimental approaches he obtained information on the structure and function of somatostatin receptors and pharmacologically characterized novel somatostatin receptor subtype-selective analogs. After 2.5 years, he joined the Center for Molecular Recognition at Columbia University in New York, USA, where he obtained information on the structure and function of adrenergic receptors. In 2000, he joined the Department of Pharmacology of the School of Medicine at the University of Crete as an Assistant Professor, where he obtained structural and functional information for the type 1 receptor (CRF1R) for the corticotropin-releasing factor (CRF). From 09/12 το 08/13, he was an adjunct professor in the Department of Physiology and Biophysics at the University of Virginia Commonwealth University in Richmond, USA. In addition, Dr. Liapakis, in collaboration with medicinal chemists and molecular modelers, pharmacologically characterized many novel analogs, which target the CRF, angiotensin, and gonadotropin-releasing hormone receptors. His research work has been funded by several different funding organizations and has been published in numerous high-profile international scientific journals.