Mastrodimou Niki
November 19, 2025 2025-11-19 10:43Mastrodimou Niki
Mastrodimou Niki
Chemistry - Biochemistry
Medical School, University of Crete, P.C. 70013 Heraklion, Crete
Niki Mastrodimou is a member of the Laboratory Teaching Staff (LTS) of the Medical School of the University of Crete and teaches in the Undergraduate Chemistry and Biochemistry Laboratories.
She is a graduate of the Department of Chemistry of the University of Crete and holds a PhD from the Department of Medicine of the University of Crete.
– Degree in Chemistry from the Department of Chemistry, University of Crete.
– Doctorate (PhD) from the Department of Medicine, School of Health Sciences, University of Crete.
Development of models of retinopathy (e.g. diabetic retinopathy) in rodents, in vivo and in vitro. Use of the models to study the neuroprotective effects of various analogues such as somatostatiners, cannabinoids, neurotrophins and NO inhibitors. Pharmacological characterization of substances with binding studies.
1. Grigoryan EN, Vasilaki A, Mastrodimou N, Thermos K. Somatostatin receptor immunoreactivity in the eye of the adult newt (Pleurodeles waltlii Michan). Neurosci Lett. 337(3):143-6, 2003.
2. Mastrodimou N, Thermos K. The somatostatin receptor (sst1) modulates the release of somatostatin in rat retina. Neurosci Lett. 356(1):13-6, 2004.
3. Notas G, Kolios G, Mastrodimou N, Kampa M, Vasilaki A, Xidakis C, Castanas E, Thermos K, Kouroumalis E. Cortistatin production by HepG2 human hepatocellular carcinoma cell line and distribution of somatostatin receptors. J Hepatol. 40(5):792-8, 2004.
4. Vasilaki A, Papadaki T, Notas G, Kolios G, Mastrodimou N, Hoyer D, Tsilimbaris M, Kouroumalis E, Pallikaris I, Thermos K. Effect of somatostatin on nitric oxide production in human retinal pigment epithelium cell cultures. Invest Ophthalmol Vis Sci. 45(5):1499-506, 2004.
5. Mastrodimou N, Lambrou GN, Thermos K. Effect of somatostatin analogues on chemically induced ischaemia in the rat retina. Naunyn Schmiedebergs Arch Pharmacol. 371(1):44-53, 2005.
6. Mastrodimou N, Kiagiadaki F, Hodjarova M, Karagianni E, Thermos K. Somatostatin receptors (sst2) regulate cGMP production in rat retina. Regul Pept. 133(1-3):41-6, 2005.
7. Mastrodimou N, Vasilaki A, Papadioti A, Low MJ, Hoyer D, Thermos K. Somatostatin receptors in wildtype and somatostatin deficient mice and their involvement in nitric oxide physiology in the retina. Neuropeptides. 40(5):365-73, 2006.
8. Xidakis C, Mastrodimou N, Notas G, Renieri E, Kolios G, Kouroumalis E, Thermos K. RT-PCR and immunocytochemistry studies support the presence of somatostatin, cortistatin and somatostatin receptor subtypes in rat Kupffer cells. Regul Pept.143(1-3):76-82, 2007.
9. Mastrodimou N, Kiagiadaki F, Thermos K. The role of nitric oxide and cGMP in somatostatin’s protection against retinal ischemia. Invest Ophthalmol Vis Sci.49(1):342-9, 2008.
10. Kokona D, Mastrodimou N, Pediaditakis I, Charalampopoulos I, Schmid HA, Thermos K. Pasireotide (SOM230) protects the retina in animal models of ischemia induced retinopathies. Exp Eye Res. 103:90-8, 2012.
11. Ayiomamitis G, Notas G, Zaravinos A, Drygiannakis I, Georgiadou M, Sfakianaki O, Mastrodimou N, Thermos K, Kouroumalis E. Effects of octreotide and insulin on colon cancer cellular proliferation and correlation with hTERT activity. Oncoscience. 1:457-467, 2014.
12. Ibán-Arias R, Lisa S, Mastrodimou N, Kokona D, Koulakis E, Iordanidou P, Kouvarakis A, Fothiadaki M, Papadogkonaki S, Sotiriou A, Katerinopoulos HE, Gravanis A, Charalampopoulos I, Thermos K. The Synthetic Microneurotrophin BNN27 Affects Retinal Function in Streptozotocin-Induced Diabetic Rats. Diabetes. 2018 Feb;67(2):321-333. doi: 10.2337/db17-0391. Epub 2017 Dec 5.
13. Ibán-Arias R, Lisa S, Poulaki S, Mastrodimou N, Charalampopoulos I, Gravanis A, Thermos K. Effect of topical administration of the microneurotrophin BNN27 in the diabetic rat retina. Graefes Arch Clin Exp Ophthalmol. 2019 Nov;257(11):2429-2436. doi: 10.1007/s00417-019-04460-6. Epub 2019 Sep 12.
14. Spyridakos D, Papadogkonaki S, Dionysopoulou S, Mastrodimou N, Polioudaki H, Thermos K. Effect of acute and subchronic administration of (R)-WIN55,212-2 induced neuroprotection and anti inflammatory actions in rat retina: CB1 and CB2 receptor involvement. Neurochem Int. 2021 Jan;142:104907. doi: 10.1016/j.neuint.2020.104907. Epub 2020 Nov 19.
15. Kalyvianaki K, Malamos P, Mastrodimou N, Manoura-Zonou I, Vamvoukaki R, Notas G, Malliaraki N, Moustou E, Tzardi M, Pirintsos S, Lionis C, Sourvinos G, Castanas E, Kampa M. Toxicity evaluation of an essential oil mixture from the Cretan herbs thyme, Greek sage and Cretan dittany. NPJ Sci Food. 2020 Nov 9;4(1):20. doi: 10.1038/s41538-020-00080-1.
16. Spyridakos D, Mastrodimou N, Vemuri K, Ho TC, Nikas SP, Makriyannis A, Thermos K. Blockade of CB1 or Activation of CB2 Cannabinoid Receptors Is Differentially Efficacious in the Treatment of the Early Pathological Events in Streptozotocin-Induced Diabetic Rats. Int J Mol Sci. 2022 Dec 23;24(1):240. doi: 10.3390/ijms24010240.
17. Dionysopoulou S, Wikstrom P, Bucolo C, Romano GL, Micale V, Svensson R, Spyridakos D, Mastrodimou N, Georgakis S, Verginis P, Walum E, Thermos K. Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy. Diabetes. 2023 May 1;72(5):638-652. doi: 10.2337/db22-0515.
Association of Greek Chemists
