Signaling pathways to and from the cytoskeleton and tight junction complexes.

Feger M, Tsapara A, Hülße S, Rausch S, Barholz M, Stournaras C, Föller M., Chorein regulates key osteoblast genes in UMR-106 cells, Cell Biochem Biophys., Protein J., 2025, on line ahead of print.
Tzenaki N, Xenou L, Goulielmaki E, Tsapara A, Voudouri I, Antoniou A, Valianatos G, Tzardi M, De Bree E, Berdiaki A, Makrigiannakis A, Papakonstanti EA., A combined opposite targeting of p110δ PI3K and RhoA abrogates skin cancer, Commun Biol., 2024, 7:26.
Deiktakis EE, Abrams M, Tsapara A, Stournaras C, Tsatsanis C, Tsichlis PN, Kampranis SC., Identification of structural elements of the lysine specific demethylase 2B CxxC domain associated with replicative senescence bypass in primary mouse cells, Protein J., 2020, 39:232-239.
Zacharopoulou N, Kallergi G, Alkahtani S, Tsapara A, Alarifi S, Schmid E, Sukkar B, Kampranis S, Lang F, Stournaras C., The histone demethylase KDM2B activates FAK and PI3K that control tumor cell motility, Cancer Biol Ther., 2020, 21:533-540.
Zacharopoulou N, Tsapara A, Kallergi G, Schmid E, Tsichlis PN, Kampranis SC, Stournaras C., The epigenetic factor KDM2B regulates cell adhesion, small rho GTPases, actin cytoskeleton and migration in prostate cancer cells, Biochim Biophys Acta Mol Cell Res., 2018, 1865:587-597.
Zacharopoulou N, Tsapara A, Kallergi G, Schmid E, Alkahtani S, Alarifi S, Tsichlis PN, Kampranis SC, Stournaras C., The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells, Cell Physiol Biochem., 2018, 47:368-377.
Stagno MJ, Zacharopoulou N, Bochem J, Tsapara A, Pelzl L, Al-Maghout T, Kallergi G, Alkahtani S, Alevizopoulos K, Dimas K, Calogeropoulou T, Warmann SW, Lang F, Schmid E, Stournaras C., Istaroxime Inhibits Motility and Down-Regulates Orai1 Expression, SOCE and FAK Phosphorylation in Prostate Cancer Cells, Cell Physiol Biochem., 2017, 42:1366-1376.
Eden ER, Sanchez-Heras E, Tsapara A, Sobota A, Levine TP, Futter CE, Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport, Dev Cell., 2016, 37:473-83.
Alevizopoulos K, Dimas K, Papadopoulou N, Schmidt EM, Tsapara A, Alkahtani S, Honisch S, Prousis KC, Alarifi S, Calogeropoulou T, Lang F, Stournaras C, Functional characterization and anti-cancer action of the clinical phase II cardiac Na+/K+ ATPase inhibitor istaroxime: in vitro and in vivo properties and cross talk with the membrane androgen receptor, Oncotarget, 2016, 7:24415-28.
Honisch S, Yu W, Liu G, Alesutan I, Towhid ST, Tsapara A, Schleicher S, Handgretinger R, Stournaras C, Lang F, Chorein addiction in VPS13A overexpressing rhabdomyosarcoma cells, Oncotarget, 2015, 6:10309-19.
Honisch S, Gu S, Vom Hagen JM, Alkahtani S, Al Kahtane AA, Tsapara A, Hermann A, Storch A, Schöls L, Lang F, Stournaras C, Chorein Sensitive Arrangement of Cytoskeletal Architecture, Cell Physiol Biochem., 2015, 7:399-408.
Eden E.R., White I.J., Tsapara A. and Futter C.E., Membrane contacts between endosomes and ER provide sites for PTP1B-EGF receptor interaction, Nat Cell Biol, 2010, 12: 267-272.
Tsapara A., Luthert P., Greenwood J., Hill C.S., Matter K. and Balda M.S., The RhoA activator GEF-H1/Lfc is a TGF- target gene and effector that regulates -smooth muscle actin expression and cell migration, Mol. Biol. Cell, 2010, 21:860-870.
Tsapara A., Matter K and Balda M.S., The heat shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB, Mol. Biol. Cell, 2006, 17: 1322-1330.
Kavanagh E, Buchert M, Tsapara A, Choquet A, Balda MS, Hollande F, Matter K, Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin, J. Cell Sci., 2006, 119: 5098-5105.
Sourisseau T., Georgiadis A, Tsapara A., Ali R.R., Pestell R., Matter K., Balda M.S., Regulation of PCNA and Cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA, Mol. Cell. Biol., 2006, 26:2387-2398.
Matter K, Aijaz S, Tsapara A, Balda MS, Mammalian tight junctions in the regulation of epithelial differentiation and proliferation, Curr Opin Cell Biol, 2005, 17:453-8.
Kallergi G, Tsapara A, Kampa M, Papakonstanti EA, Krasagakis K, Castanas E, Stournaras C, Distinct signaling pathways regulate differential opioid effects on actin cytoskeleton in malignant MCF7 and nonmalignant MCF12A human breast epithelial cells, Exp. Cell Res., 2003, 288: 94-109.
Tsapara A, Kardassis D, Moustakas A, Gravanis A, Stournaras C, Expression and characterization of Cys374 mutated human -actin in two different mammalian cell lines: impaired microfilament organization and stability, FEBS Lett., 1999, 455: 117-12.
Theodoropoulos PA, Gravanis A, Tsapara A, Margioris AN, Papadogiorgaki E, Galanopoulos V, Stournaras, Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping, Biochem. Pharmacol., 1994, 47:1875-1881.

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