Απεικόνιση εγκεφάλου κατά την μάθηση μέσω παρατήρησης: Χρήση MEG καθώς και της ποσοτικής, αυτοραδιογραφικής τεχνικής 14C-δεοξυγλυκόζης, με ανάλυση εικόνας και δισδιάστατη ανακατασκευή της τοπικής εγκεφαλικής χρήσης γλυκόζης χρησιμοποιείται προκειμένου να ερευνηθούν: 1) οι φλοιώδεις εγκεφαλικές οδοί που σχετίζονται με εκούσιες κινήσεις πιθήκων που εκτελούν μαθημένες οπτικο-σκελετοκινητικές κινήσεις με οπτική ή σωματοαισθητική καθοδήγηση του βραχίονα, 2) φλοιώδεις και υποφλοιώδεις περιοχές, που σχετίζονται με σακαδικές κινήσεις των ματιών στον εγκέφαλο του πιθήκου και πώς κωδικοποιούν παραμέτρους των σακκάδων (κατεύθυνση, πλάτος, θέση ματιού και τροχιά), 3) περιοχές του φλοιού που εμπλέκονται στην εκτέλεση κινήσεων σύλληψης που καθοδηγούνται είτε από αισθητικά ερεθίσματα είτε σε απομνημονευμένες θέσεις στο σκοτάδι, καθώς και περιοχών που εμπλέκονται στην παρατήρηση των ενεργειών που εκτελούνται από άλλους.

A. Articles in peer-reviewed journals

1. Savaki HE, Kavroulakis E, Papadaki E, Maris T, Simos P. Action Observation Responses Are Influenced by Movement Kinematics and Target Identity. Cerebral Cortex, 32:490–503, 2022.
2. Savaki HE, Raos V. Action perception and motor imagery: Mental practice of action. Progr Neurobiol, 175:107-125, 2019.
3. Savaki H. A specific immunity brain aging gene with a future. EBioMedicine, 36:9, 2018.
4. Simos P, Kavroulakis E, Maris T, Papadaki E, Boursianis T, Kalaitzakis G, Savaki HE. Neural foundations of overt and covert actions. NeuroImage, 152:482-496, 2017.
5. Raos V, Savaki HE. Perception of actions performed by external agents presupposes knowledge about the relationship between action and effect. NeuroImage, 132:261-73, 2016.
6. Raos V, Savaki HE. The Role of the Prefrontal Cortex in Action Perception. Cereb Cortex, 1–14, 2016.
7. Savaki HE, Gregoriou GG, Bakola S Moschovakis AK.. Topography of visuomotor parameters in the frontal and premotor eye fields Cereb Cortex, 25:3095-3106, 2015.
8. Kilintari M, Raos V, Savaki HE. Involvement of the superior temporal cortex in action execution and action observation. J. Neurosci. 34:8999-9011, 2014.

9. Savaki HE, Gregoriou GG, Bakola S Moschovakis AK.. Topography of visuomotor parameters in the frontal and premotor eye fields Cereb Cortex, 2014 May 20. pii: bhu106.

10. Raos V, Kilintari M, Savaki HE. Viewing a forelimb induces widespread cortical activations. Neuroimage.89:122-142, 2014.

11. Kilintari M, Raos V, Savaki HE. Grasping in the dark activates early visual cortices. Cereb Cortex 21:949-63, 2011.

12. Hourdakis E, Savaki H.E, Trahanias P Computational modeling of cortical pathways involved in action execution and action observation. Neurocomputing 74:1135-1155, 2011
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13. Savaki HE. How do we understand the actions of others? By mental simulation, NOT mirroring. Cognitive Critique, 2: 99-140, 2010.

14. Stamos AV, Savaki HE, Raos V. The spinal substrate of the suppression of action during action observation. J. Neurosci. 30:11605-11, 2010.

15. Savaki HE, Gregoriou GG, Bakola S, Raos V, Moschovakis AK. The place code of saccade metrics in the lateral bank of the intraparietal sulcus. J. Neurosci.30:1118-1127, 2010.

16. Evangeliou MN, Raos V, Galletti C, and Savaki HE. Functional imaging of the parietal cortex during action execution and observation. Cereb Cortex 19: 624-639, 2009.

17. Raos V, Evangeliou MN, and Savaki HE. Mental simulation of action in the service of action perception. J Neurosci 27: 12675-12683, 2007.

18. Bakola S, Gregoriou GG, Moschovakis AK, Raos V, and Savaki HE. Saccade-related information in the superior temporal motion complex: quantitative functional mapping in the monkey. J Neurosci 27: 2224-2229, 2007.

19. Bakola S, Gregoriou GG, Moschovakis AK, and Savaki HE. Functional imaging of the intraparietal cortex during saccades to visual and memorized targets. Neuroimage 31: 1637-1649, 2006.

20. Gregoriou GG, Luppino G, Matelli M, and Savaki HE. Frontal cortical areas of the monkey brain engaged in reaching behavior: a 14C-deoxyglucose imaging study. Neuroimage 27: 442-464, 2005.

21. Raos V, Evangeliou MN, and Savaki HE. Observation of action: grasping with the mind’s hand. Neuroimage 23: 193-201, 2004.

22. Moschovakis AK, Gregoriou GG, Ugolini G, Doldan M, Graf W, Guldin W, Hadjidimitrakis K, and Savaki HE. Oculomotor areas of the primate frontal lobes: a transneuronal transfer of rabies virus and [14C]-2-deoxyglucose functional imaging study. J Neurosci 24: 5726-5740, 2004.

23. Gregoriou GG, and Savaki HE. When vision guides movement: a functional imaging study of the monkey brain. Neuroimage 19: 959-967, 2003.

24. Moschovakis AK, Gregoriou GG, and Savaki HE. Functional imaging of the primate superior colliculus during saccades to visual targets. Nat Neurosci 4: 1026-1031, 2001.

25. Gregoriou GG, and Savaki HE. The intraparietal cortex: subregions involved in fixation, saccades, and in the visual and somatosensory guidance of reaching. J Cereb Blood Flow Metab 21: 671-682, 2001.

26. Savaki HE. Sokoloff’s 14C-deoxyglucose method. Brain Res Bull 50: 405-407, 1999.

27. Savaki HE, and Dalezios Y. 14C-deoxyglucose mapping of the monkey brain during reaching to visual targets. Prog Neurobiol 58: 473-540, 1999.

28. Dalezios Y, Gregoriou GG, and Savaki HE. Metabolic activity patterns in the monkey visual cortex as revealed by spectral analysis. J Cereb Blood Flow Metab 19: 401-416, 1999.

29. Savaki HE, Raos VC, and Dalezios Y. Spatial cortical patterns of metabolic activity in monkeys performing a visually guided reaching task with one forelimb. Neuroscience 76: 1007-1034, 1997.

30. Savaki HE, Kennedy C, Sokoloff L, and Mishkin M. Visually guided reaching with the forelimb contralateral to a “blind” hemisphere in the monkey: contribution of the cerebellum. Neuroscience 75: 143-159, 1996.

31. Dalezios Y, Raos VC, and Savaki HE. Metabolic activity pattern in the motor and somatosensory cortex of monkeys performing a visually guided reaching task with one forelimb. Neuroscience 72: 325-333, 1996.

32. Raos VC, Dermon CR, and Savaki HE. Functional anatomy of the thalamic centrolateral nucleus as revealed with the [14C]deoxyglucose method following electrical stimulation and electrolytic lesion. Neuroscience 68: 299-313, 1995.

33. Raos VC, and Savaki HE. Functional anatomy of the thalamic reticular nucleus as revealed with the [14C]deoxyglucose method following electrical stimulation and electrolytic lesion. Neuroscience 68: 287-297, 1995.

34. Tzagournissakis M, Dermon CR, and Savaki HE. Functional metabolic mapping of the rat brain during unilateral electrical stimulation of the subthalamic nucleus. J Cereb Blood Flow Metab 14: 132-144, 1994.

35. Savaki HE, Kennedy C, Sokoloff L, and Mishkin M. Visually guided reaching with the forelimb contralateral to a “blind” hemisphere: a metabolic mapping study in monkeys. J Neurosci 13: 2772-2789, 1993.

36. Savaki HE, Raos VC, and Dermon CR. Bilateral cerebral metabolic effects of pharmacological manipulation of the substantia nigra in the rat: unilateral intranigral application of the inhibitory GABAA receptor agonist muscimol. Neuroscience 50: 781-794, 1992.

37. Dermon CR, Tzagournissakis M, and Savaki HE. Bilateral cerebral metabolic effects of pharmacological manipulation of the substantia nigra in the rat: unilateral intranigral application of the putative excitatory neurotransmitter substance P. Neuroscience 50: 795-809, 1992.

38. Dermon CR, Pizarro P, Georgopoulos P, and Savaki HE. Bilateral alterations in local cerebral glucose utilization following intranigral application of the GABAergic agonist muscimol. J Neurosci 10: 2861-2878, 1990.

39. Savaki HE, Pizarro P, Dermon C, and Arsenis S. Deoxyglucose analysis of the specific topographic functional interrelations between substantia nigra and globus pallidus. Brain Res Bull 21: 855-863, 1988.

40. Girault JA, Spampinato U, Savaki HE, Glowinski J, and Besson MJ. In vivo release of [3H]gamma-aminobutyric acid in the rat neostriatum–I. Characterization and topographical heterogeneity of the effects of dopaminergic and cholinergic agents. Neuroscience 19: 1101-1108, 1986.

41. Spampinato U, Girault JA, Danguir J, Savaki HE, Glowinski J, and Besson MJ. Apomorphine and haloperidol effects on striatal 3H-dopamine release in anesthetized, awake restrained and freely moving rats. Brain Res Bull 16: 161-166, 1986.

42. Savaki HE, Girault JA, Spampinato U, Truong NA, Glowinski J, and Besson MJ. Release of newly synthesized 3H-dopamine in the striatum: an adaptation of the push-pull cannula method to awake restrained and anesthetized rats. Brain Res Bull 16: 149-154, 1986.

43. Girault JA, Savaki HE, Desban M, Glowinski J, and Besson MJ. [Effect of lesions of the ventromedial nucleus of the thalamus on cerebral metabolism: experimental study in the rat using the 14C-deoxyglucose method]. Rev Neurol (Paris) 142: 456-464, 1986.

44. Benavides J, Malgouris C, Daniel M, Savaki H, Uzan A, Gueremy C, and Le Fur G. [Biochemical characterization and study by quantitative autoradiography of the binding sites of indalpine, a 5-HT uptake inhibitor, in cat brain]. Encephale 11: 247-254, 1985.

45. Savaki H, Malgouris C, Benavides J, Laplace C, Uzan A, Gueremy C, and Le Fur G. Quantitative autoradiography of [3H]indalpine binding sites in the rat brain: II. Regional distribution. J Neurochem 45: 521-526, 1985.

46. Benavides J, Savaki HE, Malgouris C, Laplace C, Margelidon C, Daniel M, Courteix J, Uzan A, Gueremy C, and Le Fur G. Quantitative autoradiography of [3H]indalpine binding sites in the rat brain: I. Pharmacological characterization. J Neurochem 45: 514-520, 1985.

47. Savaki HE, Girault JA, Desban M, Glowinski J, and Besson MJ. Local cerebral metabolic effects induced by nigral stimulation following ventromedial thalamic lesions. II: Sensory motor, reticular and limbic systems. Brain Res Bull 14: 287-296, 1985.

48. Girault JA, Savaki HE, Desban M, Glowinski J, and Besson MJ. Bilateral cerebral metabolic alterations following lesion of the ventromedial thalamic nucleus: mapping by the 14C-deoxyglucose method in conscious rats. J Comp Neurol 231: 137-149, 1985.

49. Benavides J, Savaki HE, Malgouris C, Laplace C, Daniel M, Begassat F, Desban M, Uzan A, Dubroeucq MC, Renault C, and et al. Autoradiographic localization of peripheral benzodiazepine binding sites in the cat brain with [3H]PK 11195. Brain Res Bull 13: 69-77, 1984.

50. Savaki HE, Girault JA, Desban M, Glowinski J, and Besson MJ. Adaptive reaction of nigral neurons following lesion of their ventromedial-thalamic projection field. Brain Res 302: 190-195, 1984.

51. Savaki HE, Girault JA, Desban M, Glowinski J, and Besson MJ. Local cerebral metabolic effects induced by nigral stimulation following ventromedial thalamic lesions. I: Basal ganglia and related motor structures. Brain Res Bull 12: 609-616, 1984.

52. Savaki HE, Graham DI, Grome JJ, and McCulloch J. Functional consequences of unilateral lesion of the locus coeruleus: a quantitative [14C]2-deoxyglucose investigation. Brain Res 292: 239-249, 1984.

53. Kadekaro M, Savaki HE, Kutyna FA, Davidsen L, and Sokoloff L. Metabolic mapping in the sympathetic ganglia and brain of the spontaneously hypertensive rat. J Cereb Blood Flow Metab 3: 460-467, 1983.

54. Savaki HE, Graham DI, and McCulloch J. Differential effects of locus coeruleus lesions upon metabolic activity in CNS nuclei involved in cardiovascular regulation. Brain Res 271: 109-114, 1983.

55. Savaki HE, Desban M, Glowinski J, and Besson MJ. Local cerebral glucose consumption in the rat. II. Effects of unilateral substantia nigra stimulation in conscious and in halothane-anesthetized animals. J Comp Neurol 213: 46-65, 1983.

56. Savaki HE, Desban M, Glowinski J, and Besson MJ. Local cerebral glucose consumption in the rat. I. Effects of halothane anesthesia. J Comp Neurol 213: 36-45, 1983.

57. McCulloch J, Savaki HE, and Sokoloff L. Distribution of effects of haloperidol on energy metabolism in the rat brain. Brain Res 243: 81-90, 1982.

58. McCulloch J, Savaki HE, McCulloch MC, Jehle J, and Sokoloff L. The distribution of alterations in energy metabolism in the rat brain produced by apomorphine. Brain Res 243: 67-80, 1982.

59. McCulloch J, Savaki HE, Jehle J, and Sokoloff L. Local cerebral glucose utilization in hypothermic and hyperthermic rats. J Neurochem 39: 255-258, 1982.

60. Savaki HE, Macpherson H, and McCulloch J. Alterations in local cerebral glucose utilization during hemorrhagic hypotension in the rat. Circ Res 50: 633-644, 1982.

61. Savaki HE, Kadekaro M, McCulloch J, and Sokoloff L. The central noradrenergic system in the rat: metabolic mapping with alpha-adrenergic blocking agents. Brain Res 234: 65-79, 1982.

62. Savaki HE, McCulloch J, Kadekaro M, and Sokoloff L. Influence of alpha-receptor blocking agents upon metabolic activity in nuclei involved in central control of blood pressure. Brain Res 233: 347-358, 1982.

63. Savaki HE, Davidsen L, Smith C, and Sokoloff L. Measurement of free glucose turnover in brain. J Neurochem 35: 495-502, 1980.

64. McCulloch J, Savaki HE, and Sokoloff L. Influence of dopaminergic systems on the lateral habenular nucleus of the rat. Brain Res 194: 117-124, 1980.

65. Kadekaro M, Savaki H, and Sokoloff L. Metabolic mapping of neural pathways involved in gastrosecretory response to insulin hypoglycaemia in the rat. J Physiol 300: 393-407, 1980.

66. McCulloch J, Savaki HE, McCulloch MC, and Sokoloff L. Retina-dependent activation by apomorphine of metabolic activity in the superficial layer of the superior colliculus. Science 207: 313-315, 1980.

67. Mata M, Fink DJ, Gainer H, Smith CB, Davidsen L, Savaki H, Schwartz WJ, and Sokoloff L. Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity. J Neurochem 34: 213-215, 1980.

68. McCulloch J, Savaki HE, McCulloch MC, and Sokoloff L. Specific distribution of metabolic alterations in cerebral cortex following apomorphine administration. Nature 282: 303-305, 1979.

69. Schwartz WJ, Smith CB, Davidsen L, Savaki H, Sokoloff L, Mata M, Fink DJ, and Gainer H. Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat. Science 205: 723-725, 1979.

70. Pappius HM, Savaki HE, Fieschi C, Rapoport SI, and Sokoloff L. Osmotic opening of the blood-brain barrier and local cerebral glucose utilization. Ann Neurol 5: 211-219, 1979.

71. Wechsler LR, Savaki HE, and Sokoloff L. Effects of d- and l-amphetamine on local cerebral glucose utilization in the conscious rat. J Neurochem 32: 15-22, 1979.

72. Savaki HE, Kadekaro M, Jehle J, and Sokoloff L. Alpha- and beta-adrenoreceptor blockers have opposite effects on energy metabolism of the central auditory system. Nature 276: 521-523, 1978.

73. Savaki HE, and Levis GM. Changes in rat brain gangliosides following active avoidance conditioning. Pharmacol Biochem Behav 7: 7-12, 1977.

74. Savaki HE, Cunha J, Carlini EA, and Kephalas TA. Pharmacological activity of three fractions obtained by smoking cannabis through a water pipe. Bull Narc 28: 49-56, 1976.

B. Books and book chapters

1. Savaki H.E.: «Οι Παράλληλοι Εαυτοί μας και το Βουβό Δεξί Ηισφαίριο» (Our parallel Selves and the Mute Right Hemisphere), Crete University Press, Greece, 1989.

2. Savaki H.E.: The role of thalamic relays in the basal ganglia interhemispheric relations, as demonstrated by the autoradiographic 14C-deoxyglucose method. “Brain Imaging : Techniques and Applications” Ellis Horwood Ltd. Chichester, U.K.1989.

3. Savaki H.E.: Distribution of effects of catecholaminergic agents on local cerebral glucose consumption in the conscious rat. In “Catecholamines. Neuropharmacology and Central Nervous System”, vol. 2, Alan R. Liss, New York, pp. 113 – 122, 1984.

4. McCulloch J., Savaki H.E. and Angerson W.: Regional water permeability in the CNS of conscious rat. Effects of hypercapnia and locus coeruleus lesions. In “Cerebral Blood Flow: Effects of Nerves and Neurotransmitters” (Eds.) D.D. Heistad and N.L. Marcus, Elsevier, pp. 509 – 516, 1982.

5. Savaki H.E.: Neural pathway involved in regulation of blood pressure in the rat: metabolic mapping with 2-[14C] deoxyglucose of central nervous effects of phenoxybenzamine. “Les Alpha Bloquants”. MASSON, Paris, pp. 313 – 320, 1981.

6. Ελένη Σαββάκη, «Τα γερμανικά εγκλήματα και τα χρέη της Γερμανίας προς την Ελλάδα», Εκδόσεις Παπαζήση, 2024.

7. Helen Savaki “German crimes and Germany’s debts to Greece”, Εκδόσεις Φυλάτος, 2024.

8. Ελένη Σαββάκη «Η δύση της Δύσης και η ανατολή της Ανατολής», Εκδόσεις Παπαζήση, 2024

Society for Neuroscience, U.S.A (SFN).
The New York Academy of Sciences.
Hellenic Society for Neuroscience.
European Neuroscience Association (ENA).
International Brain Research Organization (IBRO).
International Society of Cerebral Blood Flow and Metabolism.
International Neuropsychological Symposium (INS).